<Suppliers Price>

Dapansutrile

Names

[ CAS No. ]:
54863-37-5

[ Name ]:
Dapansutrile

[Synonym ]:
2-methyl-2H-isoindole-1-carbonitrile
2H-Isoindole-1-carbonitrile,2-methyl
1-cyano-2-methylisoindole
3-methanesulfonylpropionitrile
3-(methylsulfonyl)propionitrile
1-cyano-2-methylsulphonylethane

Biological Activity

[Description]:

Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[Target]

NLRP3 inflammasome[1]


[References]

[1]. Toldo S, et al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.

Chemical & Physical Properties

[ Molecular Formula ]:
C4H7NO2S

[ Molecular Weight ]:
133.17

[ Exact Mass ]:
133.02000

[ PSA ]:
66.31000

[ LogP ]:
1.02548

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds