1,2-Dimethyl-5-nitroimidazole

Names

[ CAS No. ]:
551-92-8

[ Name ]:
1,2-Dimethyl-5-nitroimidazole

[Synonym ]:
8595 R.P.
Dimetridazole
Unizole
EINECS 209-001-2
MFCD00047046
1,2-Dimethyl-5-nitroimidazole
Emtryl
1,2-Dimethyl-5-nitro-1H-imidazole
1H-Imidazole, 1,2-dimethyl-5-nitro-

Biological Activity

[Description]:

Dimetridazole is a nitroimidazole class drug that combats protozoan infections.Target: AntiparasiticDimetridazole (DMZ) is a 5-nitroimidazole drug traditionally used for the prevention and treatment of histomoniasis in turkeys, trichomoniasis in pigeons, genital trichomoniasis in cattle and the prevention and treatment of haemorrhagic enteritis in pigs.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

Natural Products >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
313.7±15.0 °C at 760 mmHg

[ Melting Point ]:
177-182°C

[ Molecular Formula ]:
C₅H₇N₃O₂

[ Molecular Weight ]:
141.128

[ Flash Point ]:
143.5±20.4 °C

[ Exact Mass ]:
141.053833

[ LogP ]:
0.31

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S22;S26;S36;S36/S37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NI5075000

Articles

Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 105-15, (2014)

An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their cor...

Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.

Anal. Bioanal. Chem 407 , 4423-35, (2015)

Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the deve...

Development of a rapid method for the determination and confirmation of nitroimidazoles in six matrices by fast liquid chromatography-tandem mass spectrometry.

J. Pharm. Biomed. Anal. 64-65 , 40-8, (2012)

A rapid liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to identify and to quantify nitroimidazoles, metronidazole (MNZ), ronidazole (RNZ) and dimetridazole (DMZ) and t...