4-Hydroxyisoleucine

Names

[ Name ]:
4-Hydroxyisoleucine

[Synonym ]:
4-Hydroxyisoleucine
ent-gabosine F
L-erythro-Pentonic acid, 2-amino-2,3,5-trideoxy-3-methyl-, (4ξ)-
(2S,3R)-2-Amino-4-hydroxy-3-methylpentanoic acid
2,3,4-Trihydroxy-6-methylcyclohexanone

Biological Activity

[Description]:

(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Shi X, et al. Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers. Sci Rep. 2017 Oct 20;7(1):13703.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
331.6±32.0 °C at 760 mmHg

[ Melting Point ]:
223-224℃

[ Molecular Formula ]:
C₆H₁₃NO₃

[ Molecular Weight ]:
147.172

[ Flash Point ]:
154.4±25.1 °C

[ Exact Mass ]:
147.089539

[ PSA ]:
83.55000

[ LogP ]:
-0.44

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ HS Code ]:
1302199099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%