LINAMARIN

Names

[ CAS No. ]:
554-35-8

[ Name ]:
LINAMARIN

[Synonym ]:
Phaseolunatin
2-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropanenitrile
LINAMARIN

Biological Activity

[Description]:

Linamarin, a natural compound, possesses anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Christopher Avwoghokoghene Idibie, et al. Cytotoxicity of purified cassava linamarin to a selected cancer cell lines. Bioprocess Biosyst Eng. 2007 Jul;30(4):261-9.

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
473.3ºC at 760mmHg

[ Melting Point ]:
142-143ºC

[ Molecular Formula ]:
C₁₀H₁₇NO₆

[ Molecular Weight ]:
247.24500

[ Flash Point ]:
240ºC

[ Exact Mass ]:
247.10600

[ PSA ]:
123.17000

[ Index of Refraction ]:
1.549

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ4850000

CHEMICAL NAME :: Propanenitrile, 2-(beta-D-glucopyranosyloxy)-2-methyl-

CAS REGISTRY NUMBER :: 554-35-8

BEILSTEIN REFERENCE NO. :: 0019237

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H17-N-O6

MOLECULAR WEIGHT :: 247.28

WISWESSER LINE NOTATION :: T6OTJ BQ CQ DQ EQ FOX1&1&1CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,539,1977 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 120 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 31,241,1985

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/22-36/37/38

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TZ4850000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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PLoS ONE 6(7) , e21996, (2011)

Cassava is the major source of calories for more than 250 million Sub-Saharan Africans, however, it has the lowest protein-to-energy ratio of any major staple food crop in the world. A cassava-based d...