Ms-PEG4-Ms

Names

[ CAS No. ]:
55400-73-2

[ Name ]:
Ms-PEG4-Ms

[Synonym ]:
Oxybis(2,1-ethanediyloxy-2,1-ethanediyl) dimethanesulfonate

Biological Activity

[Description]:

Ms-PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
533.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₂₂O₉S₂

[ Molecular Weight ]:
350.40600

[ Flash Point ]:
276.5ºC

[ Exact Mass ]:
350.07100

[ PSA ]:
131.19000

[ LogP ]:
1.15020

[ Index of Refraction ]:
1.47

Ms-PEG4-Ms

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds