Desoxycarbadox

Names

[ Name ]:
Desoxycarbadox

[Synonym ]:
N,N'-Desoxycarbadox
quinoxalin-2-ylmethylene-hydrazinecarboxylic acid methyl ester
Desoxycarbadox
Carbadox,deoxy

Biological Activity

[Description]:

Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vivo]

Desoxycarbadox plays a significant role in the tumorigenic activity of carbadox in rats[3].

[References]

[1]. MacIntosh AI, et al. Liquid chromatographic monitoring of the depletion of carbadox and its metabolite desoxycarbadox in swine tissues. J Assoc Off Anal Chem. 1985;68(4):665-671.

[2]. Looft T, et al. Carbadox has both temporary and lasting effects on the swine gut microbiota. Front Microbiol. 2014;5:276. Published 2014 Jun 10.

[3]. Zhang K, et al. Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and compared with its metabolites. Environ Toxicol Pharmacol. 2015;39(2):555-567.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Molecular Formula ]:
C₁₁H₁₀N₄O₂

[ Molecular Weight ]:
230.22300

[ Exact Mass ]:
230.08000

[ PSA ]:
79.96000

[ LogP ]:
1.52410

[ Index of Refraction ]:
1.634

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H302-H350

[ Precautionary Statements ]:
P201-P210-P308 + P313

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
45-11-22

[ Safety Phrases ]:
53-45

[ RIDADR ]:
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all

Articles

Residues of carbadox metabolites in edible pork products.

Arch. Toxicol. Suppl. 14 , 288-92, (1991)

Liquid chromatographic determination of carbadox, desoxycarbadox, and nitrofurazones in pork tissues.

J. Assoc. Off. Anal. Chem. 67(5) , 958-62, (1984)

A liquid chromatographic (LC) method has been developed for the determination of carbadox, desoxycarbadox, and nitrofurazones in the 10-40 ppb range in pork muscle, liver, and kidney tissues. Tissues ...

Liquid chromatographic determination of carbadox and desoxycarbadox in medicated feeds and in porcine gastrointestinal tract.

J. Assoc. Off. Anal. Chem. 68(4) , 658-60, (1985)

A liquid chromatographic method for the assay of carbadox and desoxycarbadox in medicated feeds and porcine stomach and intestinal contents is described. Samples were extracted with dimethylformamide-...