2-{2-[2-(Benzyloxy)ethoxy]ethoxy}ethanol

Names

[ Name ]:
2-{2-[2-(Benzyloxy)ethoxy]ethoxy}ethanol

[Synonym ]:
2-[2-(2-phenylmethoxyethoxy)ethoxy]ethanol
Ethanol, 2-[2-[2-(phenylmethoxy)ethoxy]ethoxy]-
MFCD02093556
2-{2-[2-(Benzyloxy)ethoxy]ethoxy}ethanol

Biological Activity

[Description]:

Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
358.0±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₀O₄

[ Molecular Weight ]:
240.296

[ Flash Point ]:
170.3±23.7 °C

[ Exact Mass ]:
240.136154

[ PSA ]:
47.92000

[ LogP ]:
0.54

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.506

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2909499000

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%