TCN 213

Names

[ Name ]:
TCN 213

Biological Activity

[Description]:

TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

GluN1/GluN2A NMDAR:0.55-40 μM (IC50)

[In Vitro]

TCN 213 (30 µM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits[1].

[References]

[1]. McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37.

[2]. Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₄N₄OS₂

[ Molecular Weight ]:
376.53900

[ Exact Mass ]:
376.13900

[ PSA ]:
127.17000

[ LogP ]:
4.20100

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%