N-Succinimidyl maleimidoacetate

Names

[ Name ]:
N-Succinimidyl maleimidoacetate

[Synonym ]:
1H-Pyrrole-2,5-dione, 1-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-
(2,5-dioxopyrrolidin-1-yl) 2-(2,5-dioxopyrrol-1-yl)acetate
MFCD00133523
1-{2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl}-1H-pyrrole-2,5-dione
N-Succinimidyl maleimidoacetate

Biological Activity

[Description]:

AMAS is a heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Alkyl/ether

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
430.1±47.0 °C at 760 mmHg

[ Melting Point ]:
174-175ºC

[ Molecular Formula ]:
C₁₀H₈N₂O₆

[ Molecular Weight ]:
252.180

[ Flash Point ]:
213.9±29.3 °C

[ Exact Mass ]:
252.038239

[ PSA ]:
101.06000

[ LogP ]:
-2.21

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.620

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%