Buflomedil

Names

[ Name ]:
Buflomedil

[Synonym ]:
4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-
Buflomedil
BufluomedilHcl
EINECS 259-851-3
AURORA KA-850
4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
4-pyrrolidin-1-yl-1-[2,4,6-tris(methyloxy)phenyl]butan-1-one
4-(Pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
MFCD00242740
4-(Pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-on
(2,4,6-Trimethoxyphenyl) (3-Pyrrolidinopropyl) Ketone

Biological Activity

[Description]:

Buflomedil is an orally active vasoactive agent. Buflomedil is an α1-, α2-adrenolytic compound. Buflomedil can be used for research of cardiovascular disease, such as peripheral vascular disease[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. de Backer TL, et al. Buflomedil for intermittent claudication. Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD000988.

[2]. Limbs International Medicinal Buflomedil (LIMB) Study Group; Leizorovicz A, Becker F. Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study. Circulation. 2008 Feb 12;117(6):816-22.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
454.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₅NO₄

[ Molecular Weight ]:
307.385

[ Flash Point ]:
228.7±28.7 °C

[ Exact Mass ]:
307.178345

[ PSA ]:
48.00000

[ LogP ]:
2.46

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.520

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL9885000

CHEMICAL NAME :: 1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-

CAS REGISTRY NUMBER :: 55837-25-7

LAST UPDATED :: 199109

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O4

MOLECULAR WEIGHT :: 307.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Fibroblast

DOSE/DURATION :: 1080 umol/L

REFERENCE :: TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,751,1990

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

[ RTECS ]:
EL9885000

[ HS Code ]:
29339990

Customs

[ HS Code ]: 29339990