Beclobrate

Names

[ CAS No. ]:
55937-99-0

[ Name ]:
Beclobrate

[Synonym ]:
Turec
Beclipur
Beclofibrat

Biological Activity

[Description]:

Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

On the normal diet rats, Beclobrate lowers total plasma cholesterol by 22-33.4% (10-50 mg/kg); the cholesterol reduction occurred mainly in high density lipoproteins (HDL). In addition, Beclobrate administration dramatically increases the activity of the high-affinity receptors for beta-VLDL in isolated liver membranes[1].

[References]

[1]. C Manzoni, et al. Differential effects of beclobrate on lipid/lipoprotein distribution in normal and hypercholesterolemic rats. Eur J Pharmacol. 1990 Nov 6;190(1-2):39-49.

Chemical & Physical Properties

[ Density]:
1.128g/cm3

[ Boiling Point ]:
437.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₃ClO₃

[ Molecular Weight ]:
346.84800

[ Flash Point ]:
149.6ºC

[ Exact Mass ]:
346.13400

[ PSA ]:
35.53000

[ LogP ]:
5.04140

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7761040

CHEMICAL NAME :: Butanoic acid, 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methyl-, ethyl ester, (+-)-

CAS REGISTRY NUMBER :: 55937-99-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H23-Cl-O3

MOLECULAR WEIGHT :: 346.88

WISWESSER LINE NOTATION :: GR D1R DOX2&1&VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,237,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4214095

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%