Fmoc-PEG3-alcohol

Names

[ CAS No. ]:
560088-66-6

[ Name ]:
Fmoc-PEG3-alcohol

[Synonym ]:
og002

Biological Activity

[Description]:

Fmoc-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.208g/cm3

[ Boiling Point ]:
581.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₅NO₅

[ Molecular Weight ]:
371.42700

[ Flash Point ]:
305.5ºC

[ Exact Mass ]:
371.17300

[ PSA ]:
77.02000

[ LogP ]:
2.94150

[ Index of Refraction ]:
1.572

Fmoc-PEG3-alcohol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds