heptaethylene glycol

Names

[ Name ]:
heptaethylene glycol

[Synonym ]:
Heptaethylene Glycol
3,6,9,12,15,18-Hexaoxaicosane-1,20-diol
3,6,9,12,15,18-Hexaoxaeicosane-1,20-diol
EINECS 227-040-3
2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Biological Activity

[Description]:

Heptaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
435.0±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₃₀O₈

[ Molecular Weight ]:
326.383

[ Flash Point ]:
216.9±27.3 °C

[ Exact Mass ]:
326.194061

[ PSA ]:
95.84000

[ LogP ]:
-3.30

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.462

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%