<Suppliers Price>

PCAF-IN-2

Names

[ CAS No. ]:
56173-05-8

[ Name ]:
PCAF-IN-2

Biological Activity

[Description]:

PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[Target]

PCAF:5.31 μM (IC50)


[In Vitro]

PCAF-IN-2 shows anti-tumour activity with IC50s of 3.06, 5.69, 7.56, 2.83 µM for HePG2, MCF-7, PC3, HCT-116 cells, respectively[1]. PCAF-IN-2 (10 µM; 24 h) induces apoptosis and arrest the cell cycle at the G2/M phase in HePG2 cells[1].

[References]

[1]. Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H7F3N6

[ Molecular Weight ]:
268.20

Related Compounds