Benzetimide hydrochloride

Names

[ Name ]:
Benzetimide hydrochloride

[Synonym ]:
Dioxatrine
1'-Benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione hydrochloride (1:1)
Spasmentral
R 4929
Benzetimide HCl
EINECS 227-072-8
[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, hydrochloride (1:1)
McN-JR4929
BENZETIMIDE HYDROCHLORIDE
Benzetimide (hydrochloride)

Biological Activity

[Description]:

Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist. Target: mAChR

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
543.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₇ClN₂O₂

[ Molecular Weight ]:
398.926

[ Flash Point ]:
282.7ºC

[ Exact Mass ]:
398.176117

[ PSA ]:
52.90000

[ LogP ]:
4.28900

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4030000

CHEMICAL NAME :: Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, hydrochloride

CAS REGISTRY NUMBER :: 5633-14-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H26-N2-O2.Cl-H

MOLECULAR WEIGHT :: 398.97

WISWESSER LINE NOTATION :: T6VMVTJ DR& D- DT6NTJ A1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37600 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,283,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)