oxybutynin

Names

[ Name ]:
oxybutynin

[Synonym ]:
cyclohexyl(hydroxy)phénylacétate de 4-(diéthylamino)but-2-yn-1-yle
Cystrin
Oxybutyninum
EINECS 202-516-5
4-(Diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
Oxybutynine
benzeneacetic acid, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester
a-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester
a-Cyclohexyl-a-hydroxybenzene acetic acid 4-(diethylamino)-2-butynyl ester
Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester
Oxybutynin Base
4-(Diethylamino)but-2-in-1-ylcyclohexyl(hydroxy)phenylacetat
4-Diethylamino-2-butynyl phenyl cyclohexylglycolate
MFCD00865252
Oxybutinin
Lyrinel XL
4-(Diethylamino)-2-butyn-1-yl cyclohexyl(hydroxy)phenylacetate
Pollakisu
4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Oxytrol
Oxybutynin
Ditropan
Oxibutinina
Oxibutyninum

Biological Activity

[Description]:

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.Target: mAChROxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder. Oxybutynin competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic, but at concentrations far above those used clinically. Oxybutynin is available orally in generic formulation or as the brand-names Ditropan, Lyrinel XL, or Ditrospam, as a transdermal patch under the brand name Oxytrol, and as a topical gel under the brand name Gelnique. Oxybutynin is also a possible treatment of hyperhidrosis (hyper-active sweating) [1-3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. Tupker, R.A., A.M. Harmsze, and V.H. Deneer, Oxybutynin therapy for generalized hyperhidrosis. Archives of dermatology, 2006. 142(8): p. 1065-1086.

[2]. Mijnhout, G., et al., Oxybutynin: dry days for patients with hyperhidrosis. Neth J Med, 2006. 64(9): p. 326-8.

[3]. Schollhammer, M. and L. Misery, Treatment of hyperhidrosis with oxybutynin. Archives of dermatology, 2007. 143(4): p. 543-551.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
494.4±45.0 °C at 760 mmHg

[ Melting Point ]:
125 - 130ºC

[ Molecular Formula ]:
C₂₂H₃₁NO₃

[ Molecular Weight ]:
357.486

[ Flash Point ]:
252.8±28.7 °C

[ Exact Mass ]:
357.230408

[ PSA ]:
49.77000

[ LogP ]:
5.19

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%