Ethyl-PEG4-alcohol

Names

[ Name ]:
Ethyl-PEG4-alcohol

[Synonym ]:
3,6,9,12-Tetraoxatetradecanol
3,6,9,12-Tetraoxa-1-tetradecanol
EINECS 227-090-6
2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethanol
tetra(ethylene glycol) monoethyl ether
3,6,9,12-Tetraoxatetradecan-1-ol

Biological Activity

[Description]:

Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.026g/cm3

[ Boiling Point ]:
302.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₂₂O₅

[ Molecular Weight ]:
222.27900

[ Flash Point ]:
136.6ºC

[ Exact Mass ]:
222.14700

[ PSA ]:
57.15000

[ LogP ]:
0.06500

[ Index of Refraction ]:
1.438

Ethyl-PEG4-alcohol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds