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Dihydroisopimaric acid

Names

[ CAS No. ]:
5673-36-9

[ Name ]:
Dihydroisopimaric acid

[Synonym ]:
1-Phenanthrenecarboxylic acid,7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-,(1theta-(1alpha,4abeta,4balpha,7alpha,10aalpha))
Podocarp-7-en-15-oic acid,13alpha-ethyl-13-methyl
Isopimaric acid,dihydro
1-Phenanthrenecarboxylic acid,7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-,(1R,4aR,4bS,7S,10aR)
Isopimaric acid,delta7-dihydro
(5ξ,13α)-Pimar-7-en-19-oic acid
delta7-Dihydroisopimaric acid
1-Phenanthrenecarboxylic acid, 7-ethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-, (1S,4aR,4bS,7S)-
15,16-Dihydroisopimaric acid
Dihydroisopimaric acid

Biological Activity

[Description]:

Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

Effects of these compounds (10 microM) on the membrane potential of HEKBKalphabeta1 were monitored by use of DiBAC(4)(3), a voltage-sensitive dye. Dihydroisopimaric acid induces substantial membrane hyperpolarization. Dihydroisopimaric acid (1-10 microM) activates BKalphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp[1].

[References]

[1]. Imaizumi Y, et al. Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. Mol Pharmacol. 2002;62(4):836-846.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
416.8±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H32O2

[ Molecular Weight ]:
304.467

[ Flash Point ]:
200.5±20.3 °C

[ Exact Mass ]:
304.240234

[ PSA ]:
37.30000

[ LogP ]:
7.10

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.529

Related Compounds