Galloflavin

Names

[ CAS No. ]:
568-80-9

[ Name ]:
Galloflavin

[Synonym ]:
3,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,6-dione

Biological Activity

[Description]:

Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[In Vitro]

Galloflavin effectively inhibits cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis[3].

[References]

[1]. Manerba M, Vettraino M, Fiume L, et al. Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem. 2012;7(2):311-317.

[2]. Farabegoli F, et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur J Pharm Sci. 2012;47(4):729-738.

[3]. Han X, et al. Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J Hematol Oncol. 2015;8:2. Published 2015 Jan 29.

Chemical & Physical Properties

[ Density]:
2.1g/cm3

[ Boiling Point ]:
159.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₆O₈

[ Molecular Weight ]:
278.17100

[ Flash Point ]:
37.4ºC

[ Exact Mass ]:
278.00600

[ PSA ]:
141.34000

[ LogP ]:
0.72180

[ Index of Refraction ]:
1.848

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%