2-Chlorophenoxazine

Names

[ CAS No. ]:
56821-03-5

[ Name ]:
2-Chlorophenoxazine

[Synonym ]:
2-chlorophenoxazine
10H-Phenoxazine,2-chloro
2-chlorphenoxazine

Biological Activity

[Description]:

2-Chlorophenoxazine is a Akt inhibitor with an IC50 value of 2-5 μM for in vitro. 2-Chlorophenoxazine can induce apoptosis.2-Chlorophenoxazine can be used for cancer diseases research[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Thimmaiah KN, et al. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J Biol Chem. 2005 Sep 9;280(36):31924-35  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8ClNO

[ Molecular Weight ]:
217.65

[ Exact Mass ]:
217.02900

[ PSA ]:
21.26000

[ LogP ]:
4.32730

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds