Captopril EP Impurity D

Names

[ Name ]:
Captopril EP Impurity D

[Synonym ]:
methacrylic acid acid
3-BROMO-2-METHYL-PROPANOIC ACID
2-methyl 3-bromopropanoic acid
2-METHYL-3-BROMOPROPIONIC ACID
3-broMo-2-Methylbutanoate
3-BROMOISOBUTYRIC ACID
Methyl-3-bromopropionicacid

Biological Activity

[Description]:

Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Chemical & Physical Properties

[ Density]:
1.625g/cm3

[ Boiling Point ]:
230.5ºC at 760mmHg

[ Molecular Formula ]:
C₄H₇BrO₂

[ Molecular Weight ]:
167.00100

[ Flash Point ]:
93.2ºC

[ Exact Mass ]:
165.96300

[ PSA ]:
37.30000

[ LogP ]:
1.10200

[ Index of Refraction ]:
1.453

MSDS

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Safety Information

[ Hazard Codes ]:
C

[ RIDADR ]:
3265

[ Packaging Group ]:
II

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%