4-Hydroxy-1H-imidazole-5-carboxamide

Names

[ Name ]:
4-Hydroxy-1H-imidazole-5-carboxamide

[Synonym ]:
5-Hydroxy-3H-imidazole-4-carboxylic acid amide
1H-Imidazole-4-carboxamide, 5-hydroxy-
4-Hydroxy-1H-imidazole-5-carboxamide

Biological Activity

[Description]:

Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Scism RA, et al. Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Org Lett. 2007 Oct 11;9(21):4179-82. Epub 2007 Sep 14.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
575.0±35.0 °C at 760 mmHg

[ Melting Point ]:
260ºC

[ Molecular Formula ]:
C₄H₅N₃O₂

[ Molecular Weight ]:
127.101

[ Flash Point ]:
301.6±25.9 °C

[ Exact Mass ]:
127.038177

[ PSA ]:
92.00000

[ LogP ]:
1.13

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.682

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KD4165600

CHEMICAL NAME :: 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-alp ha-ol, decahydro-3,6,9-trimethyl-, propionate (ester)

CAS REGISTRY NUMBER :: 56973-26-3

LAST UPDATED :: 198509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H28-O6

MOLECULAR WEIGHT :: 340.46

WISWESSER LINE NOTATION :: T6667/DP 3AAF P AXOO EO GOTJ D1 HOV2 I1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 146 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,138,1981

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%