4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

Names

[ Name ]:
4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

[Synonym ]:
1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo-
4-(2,5-dioxopyrrol-1-yl)butanoic acid
4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid
MFCD00043139
4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid

Biological Activity

[Description]:

4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
400.1±28.0 °C at 760 mmHg

[ Melting Point ]:
95-98ºC

[ Molecular Formula ]:
C₈H₉NO₄

[ Molecular Weight ]:
183.161

[ Flash Point ]:
195.8±24.0 °C

[ Exact Mass ]:
183.053162

[ PSA ]:
74.68000

[ LogP ]:
0.40

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.553

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3