6-Ketoestradiol

Names

[ CAS No. ]:
571-92-6

[ Name ]:
6-Ketoestradiol

[Synonym ]:
Estra-1,3,5(10)-trien-6-one, 3,17-dihydroxy-, (17β)-
6-ketoestradiol
(17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-one

Biological Activity

[Description]:

6-Ketoestradiol can be used to synthesize re-containing 7α-substituted estradiol complexes[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Skaddan MB, et al. Synthesis and Binding Affinities of Novel Re-Containing 7alpha-Substituted Estradiol Complexes: Models for Breast Cancer Imaging Agents. J Org Chem. 1999;64(22):8108‐8121.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
478.9±45.0 °C at 760 mmHg

[ Melting Point ]:
281-283ºC

[ Molecular Formula ]:
C₁₈H₂₂O₃

[ Molecular Weight ]:
286.366

[ Flash Point ]:
257.5±25.2 °C

[ Exact Mass ]:
286.156891

[ PSA ]:
57.53000

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.612

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation.

Bioorg. Med. Chem. 15 , 714-26, (2007)

A series of estrone and estradiol derivatives having an N-butyl,methyl heptanamide side chain at C6-position were synthesized, tested as inhibitors of type 1 17beta-HSD and assessed for their possible...

An efficient stereoselective synthesis of 6-alpha-aminoestradiol: preparation of estradiol fluorescent probes.

Steroids 62 , 462, (1997)

6-Oxoestradiol (2) was protected as its bis[(2-trimethylsilylethoxy)methyl] ether (4) and converted to the corresponding oxime (4). The oxime (4) on reduction with zinc in ethanol afforded the bis-SEM...

RP-HPLC analysis of phenolic acids of selected Central European Carex L. (Cyperaceae) species and its implication for taxonomy.

J. AOAC Int. 94 , 9-16, (2011)

Eighteen species belonging to the Carex genus were checked for the presence and the amount of eight phenolic acids (p-hydroxybenzoic, vanillic, caffeic, syringic, protocatechuic, p-coumaric, sinapic, ...