Avicularin

Names

[ CAS No. ]:
572-30-5

[ Name ]:
Avicularin

[Synonym ]:
4H-1-Benzopyran-4-one, 3-(α-L-arabinofuranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
Fenicularin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl α-L-arabinofuranoside
Quercetin 3-α-L-arabinofuranoside
Avicularin
QUERCETIN-3-ARABINOSIDE
Avicularoside
Avicularine
Avicularin,Quercetin 3-alpha-L-arabinofuranoside

Biological Activity

[Description]:

Avicularin is a bio-active flavonoid from plants, anti-inflammatory, anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF κB (p65), COX 2 and PPAR γ activities[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Vo VA, et al. Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages. Biomol Ther (Seoul). 2012 Nov;20(6):532-7.

[2]. Wang Z, et al. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities. Mol Med Rep. 2019 Jun;19(6):5417-5423.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
855.4±65.0 °C at 760 mmHg

[ Melting Point ]:
240-243ºC

[ Molecular Formula ]:
C₂₀H₁₈O₁₁

[ Molecular Weight ]:
434.350

[ Flash Point ]:
305.8±27.8 °C

[ Exact Mass ]:
434.084900

[ PSA ]:
190.28000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.802

[ Storage condition ]:
2-8C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Protective effect of components isolated from Lindera erythrocarpa against oxidative stress-induced apoptosis of H9c2 cardiomyocytes.

Phytother Res. 25(11) , 1612-7, (2011)

Eight compounds were isolated from the methanol fraction of Lindera erythrocarpa and assessed for their ability to protect H9c2 cardiomyocytes against oxidative stress-induced cell death. Three of the...

Inhibitory activity against urease of quercetin glycosides isolated from Allium cepa and Psidium guajava.

Biosci. Biotechnol. Biochem. 74 , 878-880, (2010)

Methanolic extracts of edible plants and seaweeds were tested for their inhibitory activity against Jack bean urease. Quercetin-4'-O-beta-D-glucopyranoside was isolated from Allium cepa as a urease in...

[Determination of avicularin in Polygonum aviculare L].

Yao Xue Xue Bao 18(9) , 700-4, (1983)