DQn-1
Names
[ CAS No. ]:
57343-54-1
[ Name ]:
DQn-1
Biological Activity
[Description]:
DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].
[Related Catalog]:
[In Vitro]
DQn-1 抑制 Mycobacterium tuberculosis,MIC90 值分别为 0.03 µM 和 1 µM[1]。
[In Vivo]
DQn-1 (5-10 mg/kg; p.o. for 8 days) 未能检测到小鼠 Mtb 负荷有任何显着降低[1]。
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C16H14ClN5O2
[ Molecular Weight ]:
343.77
[ Exact Mass ]:
343.08400
[ PSA ]:
128.61000
[ LogP ]:
2.69110