Fexarine

Names

[ Name ]:
Fexarine

[Synonym ]:
2-Propenoic acid, 3-[3-[[[4-(1,3-benzodioxol-5-yl)phenyl]methyl](cyclohexylcarbonyl)amino]phenyl]-, methyl ester, (2E)-
MFCD29035146
methyl (2E)-3-(3-{[4-(1,3-benzodioxol-5-yl)benzyl](cyclohexylcarbonyl)amino}phenyl)prop-2-enoate
Methyl (2E)-3-(3-{[4-(1,3-benzodioxol-5-yl)benzyl](cyclohexylcarbonyl)amino}phenyl)acrylate
Fexarine

Biological Activity

[Description]:

Fexarine is a potent, non-steroidal and selective agonist of farnesoid X receptor (EC50: 38 nM). Fexarine can be used for the research of diseases linked to cholesterol, bile acids[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Research Areas >> Metabolic Disease

[In Vitro]

Fexarine (1 μM) 诱导 HT29-FXRFL 细胞中 IBABP mRNA 的表达[1]。

[References]

[1]. Michael R. Downes, et al. Non-steroidal farnesoid X receptor modulators and methods for the use thereof.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
681.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₃₁NO₅

[ Molecular Weight ]:
497.58

[ Flash Point ]:
365.8±31.5 °C

[ Exact Mass ]:
497.220215

[ LogP ]:
6.34

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.634