1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan

Names

[ Name ]:
1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan

[Synonym ]:
6(2H)-Benzofuranone, 2-(1,3-benzodioxol-5-yl)-3,5-dihydro-5-methoxy-3-methyl-5-(2-propen-1-yl)-, (2S,3S,5S)-
(2S,3S,5S)-5-Allyl-2-(1,3-benzodioxol-5-yl)-5-methoxy-3-methyl-3,5-dihydro-1-benzofuran-6(2H)-one

Biological Activity

[Description]:

1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan, a lignan derivative from the ethyl acetate soluble fraction of twigs of Magnolia denudate (Magnoliaceae), exhibits anti-platelet-activating factor (PAF) activity. PAF is a potent lipid mediator in inflammation and asthma[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. M Kuroyanagi, et al. Bicyclo[3.2.1]octane and 6-oxabicyclo[3.2.2]nonane type neolignans from Magnolia denudate. Chem Pharm Bull (Tokyo). 2000 Jun;48(6):832-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
490.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₅

[ Molecular Weight ]:
340.370

[ Flash Point ]:
216.3±28.8 °C

[ Exact Mass ]:
340.131073

[ PSA ]:
53.99000

[ LogP ]:
2.86

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.603

Safety Information

[ Hazard Codes ]:
Xi