Hydrocortisone Valerate

Names

[ Name ]:
Hydrocortisone Valerate

[Synonym ]:
CORTISOL 17-VALERATE
Flexicort
Westcort
HYDROCORTISONEVALERATE,USP
Hydrocortisone Valerate (200 mg)
cortisol valerate
hydrocortisone valerat
hydrocortisone-17-valerate
HYDROCORTISONE VALERATE

Biological Activity

[Description]:

Hydrocortisone 17-valerate (Cortisol 17-valerate) is a thiazolidine compound[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Bodor N, et al. Soft drugs 4. 3-Spirothiazolidines of hydrocortisone and its derivatives[J]. International Journal of Pharmaceutics, 1982, 10(4): 307-321.

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
595.1ºC at 760mmHg

[ Melting Point ]:
217-220 °C

[ Molecular Formula ]:
C₂₆H₃₈O₆

[ Molecular Weight ]:
446.57600

[ Flash Point ]:
195ºC

[ Exact Mass ]:
446.26700

[ PSA ]:
100.90000

[ LogP ]:
3.52270

[ Index of Refraction ]:
1.56

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate.

J. Am. Acad. Dermatol. 21(5 Pt 1) , 979-84, (1989)

Compounding compatibility studies of four corticosteroid cream products and four commonly added chemicals are presented. Physical alteration, chemical stability, micropreservative challenge status, an...

Addition of a topically applied corticosteroid to a modified Goeckerman regimen for treatment of psoriasis: effect on duration of remission.

J. Am. Acad. Dermatol. 13(5 Pt 1) , 784-91, (1985)

A double-blind parallel group study was undertaken to assess the effect of adding a topically applied corticosteroid cream to a modified Goeckerman regimen to treat patients with psoriasis. Nineteen p...

Temporal infiltration of leukocyte subsets into mouse skin inflamed with phorbol ester.

Agents Actions 37(3-4) , 260-7, (1992)

We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by e...