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Ethacizine hydrochloride

Names

[ CAS No. ]:
57530-40-2

[ Name ]:
Ethacizine hydrochloride

[Synonym ]:
Ethacizine hydrochloride

Biological Activity

[Description]:

Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Cardiovascular Disease

[In Vivo]

NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator[1].

[References]

[1]. Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12.

[2]. Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98(3):827-32.Med Chem. 2019 Nov 6:115132.

Chemical & Physical Properties

[ Boiling Point ]:
576.7ºC at 760mmHg

[ Molecular Formula ]:
C22H28ClN3O3S

[ Molecular Weight ]:
449.99400

[ Flash Point ]:
302.6ºC

[ Exact Mass ]:
449.15400

[ PSA ]:
90.67000

[ LogP ]:
5.99680

Related Compounds