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vitamin D3

Names

[ CAS No. ]:
57651-82-8

[ Name ]:
vitamin D3

[Synonym ]:
(3R,5Z,7E)-9,10-seco-cholesta-5,7,10(19)-trien-3-ol
(R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol
3-epi-vitamin D

Biological Activity

[Description]:

3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[In Vitro]

3-epi-Vitamin D3 (Epicholecalciferol) (5 or 10 μM) significantly upregulates Cyp24A1 in U87MG, HT-29 and C3H10T1/2 cells[1].

[References]

[1]. Banerjee U, et al. Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitors. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1330-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H44O

[ Molecular Weight ]:
384.63800

[ Exact Mass ]:
384.33900

[ PSA ]:
20.23000

[ LogP ]:
7.61900

Related Compounds