CHITOBIOSE DIHYDROCHLORIDE

Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units[1]. Chitobiose has orally activity and high antioxidant activity[2].

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chitobiose (30, 100, 300 mg/kg; p.o., single) can enters the circulatory system when given orally[2]. Pharmacokinetic Parameters of Chitobiose in Wistar strain male rats[2]. PO (30 mg/kg) PO (100 mg/kg) PO (300 mg/kg) Tmax (h) 0.9 1.0 1.8 Cpmax (μg/mL) 1.1 4.4 6.9 AUC0-4h (μg·h/mL) 2.5 9.0 17.6 AUMC0-4h (μg·h^2/mL) 4.0 13.2 35.6 MRT (h) 1.6 1.5 1.6 MAT (h) 1.1 1.0 1.2 ka (h^-1) 0.95 0.99 0.96 F1-4h (%) 1.8 2.0 1.3 Animal Model: Wistar strain male rats (7 weeks, 165-185 g)[2] Dosage: 30, 100, 300 mg/kg Administration: p.o., single (Pharmacokinetics analysis) Result: Entered the circulatory system when given orally.

[1]. Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020;2020:2394704. Published 2020 Apr 11.

[2]. Chen AS, Taguchi T, Okamoto H, et al. Pharmacokinetics of chitobiose and chitotriose administered intravenously or orally to rats. Biol Pharm Bull. 2005;28(3):545-548.