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WAY 629 hydrochloride

Names

[ CAS No. ]:
57756-44-2

[ Name ]:
WAY 629 hydrochloride

[Synonym ]:
MFCD06798323
[1,4]Diazepino[6,7,1-jk]carbazole, 1,2,3,4,8,9,10,11-octahydro-, hydrochloride (1:1)
1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride (1:1)
WAY 629 hydrochloride

Biological Activity

[Description]:

WAY 629 hydrochloride is a potent and selective 5-HT2C agonist with EC50s of 426, 260000 nM for 5-HT2C and 5-HT2A, respectively. WAY 629 hydrochloride decreases feeding behavior[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT2C Receptor:426 nM (EC50)

5-HT2A Receptor:260000 nM (EC50)


[In Vivo]

WAY 629 hydrochloride (30 mg/kg; i.p.) 降低大鼠的进食行为[1]。 WAY 629 hydrochloride (30 mg/kg; i.p.) 降低小鼠大脑中 NPY mRNA 的表达[2]。 Animal Model: WT mice[2] Dosage: 21 mg/kg Administration: I.p. Result: Decreased the expression of NPY mRNA.

[References]

[1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7.  

[2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H19ClN2

[ Molecular Weight ]:
262.778

[ Exact Mass ]:
262.123688

Related Compounds