carazolol

Names

[ Name ]:
carazolol

[Synonym ]:
Conduction
1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
carazolol
CARAZOLOL HYDROCHLORIDE
1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol
EINECS 260-945-1
1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
suacron
MFCD03428052
2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]-
Carazololum
Conducton

Biological Activity

[Description]:

Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β1 adrenoceptor

β2 adrenoceptor

β3 adrenoceptor

[In Vivo]

Carazolol (0.01 mg/kg; i.m.; once) shows no significant side effects[2]. Animal Model: Kivircik sheeps, 25-45 kg, nonpregnant[2] Dosage: 0.01 mg/kg Administration: Intramuscular injection, once Result: Urea, creatinin, ALT, ALP, GGT, LDH, Ca, P, T.Protein, Mg, Cu levels in blood serum parameters were found to be in normal level however serum Fe, Zn levels were decreased.

[References]

[1]. A Méjean, et al. Carazolol: a potent, selective beta 3-adrenoceptor agonist. Eur J Pharmacol. 1995 Nov 30;291(3):359-66.

[2]. Remzi Gonul, et al. Effects of carazolol on electrocadiographic and trace element status in sheeps. Insights Vet Sci. 2018; 2: 001- 004.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
531.2±40.0 °C at 760 mmHg

[ Melting Point ]:
133-137 °C

[ Molecular Formula ]:
C₁₈H₂₂N₂O₂

[ Molecular Weight ]:
298.38

[ Flash Point ]:
275.1±27.3 °C

[ Exact Mass ]:
298.168121

[ PSA ]:
57.28000

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.652

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA8685000

CHEMICAL NAME :: 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((1-methylethyl)amino)-

CAS REGISTRY NUMBER :: 57775-29-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H22-N2-O2

MOLECULAR WEIGHT :: 298.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 10 ug/kg

SEX/DURATION :: female 16 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,191,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UA8685000

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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