SPDP-PEG4-acid

Names

[ Name ]:
SPDP-PEG4-acid

[Synonym ]:
17-Oxo-19-(2-pyridinyldisulfanyl)-4,7,10,13-tetraoxa-16-azanonadecan-1-oic acid
4,7,10,13-Tetraoxa-16-azanonadecan-1-oic acid, 17-oxo-19-(2-pyridinyldithio)-

Biological Activity

[Description]:

SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
677.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₀N₂O₇S₂

[ Molecular Weight ]:
462.581

[ Flash Point ]:
363.4±31.5 °C

[ Exact Mass ]:
462.149445

[ LogP ]:
0.63

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.563

SPDP-PEG4-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds