LD 490

Names

[ Name ]:
LD 490

[Synonym ]:
C 6H
2,3,6,7-tetrahydro-1H,5H-quinolizino<9,9a,1-gh>coumarin
2,3,6,7-tetrahydro-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizin-11-one
Exciton LD 490
2,3,5,6-1H,4H-tetrahydroquinolizino[9,9a,1-gh]coumarin
MFCD00227485
coumarin-6H
2,3,6,7-Tetrahydro-1H,5H,11H-(1)benzopyrano(6,7,8-ij)-quinolizin-11-one
EINECS 261-213-4
LD 490
2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one
2,3,5,6-Tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one

Biological Activity

[Description]:

Coumarin 6H, a Coumarin (Coumarin (HY-N0709)) derivative, is a laser dye. The fluorescence emission of Coumarin 6H can be enhanced by hydrogen bonding interactions[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

具有扭曲嵌段和更强供电子久洛利定基团的 Coumarin 6H 在被荧光猝灭基团抑制时表现出更高的量子产率、更好的生物相容性以及更少的背景荧光。因此，探针 LH-1 中的 Coumarin 6H 可能有助于降低背景荧光。在探针LH-1中，Coumarin 6H 荧光团的荧光不仅可以被 N-N 基团的旋转猝灭，还可以通过供体激发光诱导电子转移 (d-PET) 机制被 2,4-二硝基苯基团猝灭[2]。

[References]

[1]. P M French, et al. Passively mode-locked cw Coumarin 6 ring dye laser. Opt Lett. 1989 Feb 15;14(4):217-8.

[2]. Zhixiang Han, et al. A novel fluorescent probe with extremely low background fluorescence for sensing hypochlorite in zebrafish. Anal Biochem. 2020 Aug 1;602:113795.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
486.3ºC at 760 mmHg

[ Melting Point ]:
130 °C

[ Molecular Formula ]:
C₁₅H₁₅NO₂

[ Molecular Weight ]:
241.28500

[ Flash Point ]:
201ºC

[ Exact Mass ]:
241.11000

[ PSA ]:
33.45000

[ LogP ]:
2.55680

[ Index of Refraction ]:
1.665

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3310000

CHEMICAL NAME :: 1H,5H,11H-(1)Benzopyrano(6,7,8-ij)quinolizin-11-one, 2,3,6,7-tetrahydro-

CAS REGISTRY NUMBER :: 58336-35-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H15-N-O2

MOLECULAR WEIGHT :: 241.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,511,1985