EHNA.HCl

Names

[ Name ]:
EHNA.HCl

[Synonym ]:
(2S,3R)-3-(6-Amino-9H-purin-9-yl)-2-nonanol hydrochloride (1:1)
9H-Purine-9-ethanol, 6-amino-β-hexyl-α-methyl-, monohydrochloride
9H-Purine-9-ethanol, 6-amino-.β.-hexyl-.α.-methyl-, monohydrochloride
9H-Purine-9-ethanol, 6-amino-β-hexyl-α-methyl-, (αS,βR)-, hydrochloride (1:1)
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol hydrochloride (1:1)
EHNA hydrochloride
EHNA.HCl

Biological Activity

[Description]:

EHNA hydrochloride is a specific inhibitor of adenosine deaminase, prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase

[References]

[1]. Blázquez-Bermejo C, et al. Increased dNTP pools rescue mtDNA depletion in human POLG-deficient fibroblasts. FASEB J. 2019 Jun;33(6):7168-7179.

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
478.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₂₄ClN₅O

[ Molecular Weight ]:
313.826

[ Flash Point ]:
243ºC

[ Exact Mass ]:
313.166931

[ PSA ]:
89.85000

[ LogP ]:
3.68400

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes

Biochim. Biophys. Acta 1833(12) , 3228-36, (2013)

Autophagic flux is an important process during autophagy maturation in coronary arterial myocytes (CAMs). Here, we defined the role and molecular mechanism of the motor protein dynein in the regulatio...

Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance.

Am. J. Physiol. Lung Cell. Mol. Physiol. 301(2) , L171-80, (2011)

Mucociliary clearance, vital to lung clearance, is dependent on cilia beat frequency (CBF), coordination of cilia, and the maintenance of periciliary fluid. Adenosine, the metabolic breakdown product ...

Adenosine accelerates the healing of diabetic ischemic ulcers by improving autophagy of endothelial progenitor cells grown on a biomaterial.

Sci. Rep. 5 , 11594, (2015)

Endothelial progenitor cells (EPCs) seeded on biomaterials can effectively promote diabetic ischemic wound healing. However, the function of transplanted EPCs is negatively affected by a high-glucose ...