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Nomegestrol

Names

[ CAS No. ]:
58691-88-6

[ Name ]:
Nomegestrol

[Synonym ]:
Nomegestrol
(17a)-17-Acetyl-17-hydroxy-6-methylestra-4,6-dien-3-one
19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
Estra-4,6-dien-3-one, 17-acetyl-17-hydroxy-6-methyl-, (17α)-
17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione

Biological Activity

[Description]:

Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

[Related Catalog]:

Signaling Pathways >> Others >> Progesterone Receptor
Research Areas >> Others

[Target]

Kd: 5.44 nM (Rat uterine progesterone receptor)[1]


[In Vitro]

Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a Kd of 5.44 nM for rat uterine progesterone receptor[1]. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity[2].

[References]

[1]. Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56(6):325-8.

[2]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
502.6±50.0 °C at 760 mmHg

[ Melting Point ]:
204-205ºC

[ Molecular Formula ]:
C21H28O3

[ Molecular Weight ]:
328.45

[ Flash Point ]:
271.8±26.6 °C

[ Exact Mass ]:
328.203857

[ PSA ]:
54.37000

[ LogP ]:
2.58

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.574

[ Storage condition ]:
2~8°C

Safety Information

[ Risk Phrases ]:
63-50

[ WGK Germany ]:
3.0

Related Compounds