Benzyl-PEG1-Ms

Names

[ Name ]:
Benzyl-PEG1-Ms

[Synonym ]:
2-benzyloxyethyl mesylate
benzyl 2-methylsulphonyloxyethyl ether
2-(benzyloxy)ethyl methanesulfonate
2-benzyloxy-1-(methanesulfonyloxy)ethane
2-(phenylmethoxy)ethanol methanesulphonate
Ethanol,2-(phenylmethoxy)-,methanesulfonate
methanesulfonic acid 2-benzyloxyethyl ester

Biological Activity

[Description]:

Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.218g/cm3

[ Boiling Point ]:
375.438ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆O₅S

[ Molecular Weight ]:
248.29600

[ Flash Point ]:
180.858ºC

[ Exact Mass ]:
248.07200

[ PSA ]:
92.21000

[ LogP ]:
1.78030

[ Index of Refraction ]:
1.521

Benzyl-PEG1-Ms

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds