2'-[3-(tert-butylamino)-2-hydroxypropoxy]-5'-fluorobutyrophenone

Names

[ Name ]:
2'-[3-(tert-butylamino)-2-hydroxypropoxy]-5'-fluorobutyrophenone

[Synonym ]:
1-{2-[3-(tert-Butylamino)-2-hydroxypropoxy]-5-fluorophenyl}-1-butanone
MFCD00864575
EINECS 261-502-5
Butofilolol, (R)-
UNII:4AZC6Y5A8G
4459
4AZC6Y5A8G
Butofilolol

Biological Activity

[Description]:

Butofilolol is a potent β-blocking agent used in the research of hypertension[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[References]

[1]. Toussain P, et al. Long-term hypotensive treatment by butofilolol. Ann Cardiol Angeiol (Paris). 1983 Jun;32(4):277-83.

[2]. J P Jeanniot, et al. Butofilolol pharmacokinetics in chronic renal insufficiency. Int J Clin Pharmacol Res. 1984;4(3):165-73.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
441.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₆FNO₃

[ Molecular Weight ]:
311.392

[ Flash Point ]:
221.0±28.7 °C

[ Exact Mass ]:
311.189667

[ LogP ]:
3.33

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.503