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Sulfaquinoxaline

Names

[ CAS No. ]:
59-40-5

[ Name ]:
Sulfaquinoxaline

[Synonym ]:
sulfaquinoxaline
Benzenesulfonamide, 4-amino-N-2-quinoxalinyl-
Kokozigal
4-Amino-N-[(2E)-2(1H)-quinoxalinylidene]benzenesulfonamide
sulquin
N1-2-quinoxalylsulfanilamide
MFCD00055406
anti-k
EINECS 213-526-2
N1-(2-Quinoxalyl)sulfanilamide
sulfacox
sulphaquinoxaline
italquina
4-Amino-N-(2-quinoxalinyl)benzenesulfonamide
Benzenesulfonamide, 4-amino-N-[(2E)-2(1H)-quinoxalinylidene]-
sulfaline
4-Amino-N-(quinoxalin-2-yl)benzenesulfonamide
Compound 3-120
avicocid
SUQUIN

Biological Activity

[Description]:

Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacterial, Parasite[1][2]


[In Vivo]

Sulfaquinoxaline shows the presence of all antimicrobial residues at concentration higher than the drugs' maximum residue limit (MRL) of 100 μg/kg until two days after discontinuation of the medication[2].

[Animal admin]

For the depletion studies, 240 1-day-old Cobb chicks are used. The chickens are housed in pens that contains 30 birds each (10 birds/m2) and are provided ad libitum access to water and non-medicated feed. The chickens are randomly allocated into four experimental groups, labeled from A to D, containing 80 birds each. Chickens in group A form the untreated control group, whereas those in groups B, C and D are treated with 10 mg/kg bw of enrofloxacin, Sulfaquinoxaline or oxytetracycline, respectively, which is administered via drinking water from the 32nd to 34th day of breeding[1].

[References]

[1]. de Assis DC, et al. Evaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration. PLoS One. 2016 Nov 15;11(11):e0166402.

[2]. Urbano VR, et al. Influence of pH and ozone dose on sulfaquinoxaline ozonation. J Environ Manage. 2017 Jun 15;195(Pt 2):224-231.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
557.0±52.0 °C at 760 mmHg

[ Melting Point ]:
247-2480C

[ Molecular Formula ]:
C14H12N4O2S

[ Molecular Weight ]:
300.336

[ Flash Point ]:
290.7±30.7 °C

[ Exact Mass ]:
300.068085

[ PSA ]:
106.35000

[ LogP ]:
1.58

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.718

[ Storage condition ]:
Refrigerator

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WP2100000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-2-quinoxalinyl-
CAS REGISTRY NUMBER :
59-40-5
BEILSTEIN REFERENCE NO. :
0290026
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C14-H12-N4-O2-S
MOLECULAR WEIGHT :
300.36
WISWESSER LINE NOTATION :
T66 BN ENJ CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MahWM# Personal Communication from W.M. Mahlburg, Hopkins Agricultural Chemical Co., P.O. Box 7532, Madison, WI 53707, Nov. 16, 1982 Volume(issue)/page/year: 16NOV1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A370,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,357,1944
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1400 mg/kg/14D-I
TOXIC EFFECTS :
Blood - hemorrhage Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,357,1944 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1518 No. of Facilities: 615 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 901 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R42/43

[ Safety Phrases ]:
S22-S36/37-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
WP2100000

[ HS Code ]:
2935009090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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