tolazoline

Names

[ CAS No. ]:
59-98-3

[ Name ]:
tolazoline

[Synonym ]:
Benzidazol
Tolazolin
2-benzyl-4,5-diyhdroimidazole
2-Benzyl-4,5-dihydro-1H-imidazole
Priscol
EINECS 200-448-9
2-(phenylmethyl)-4,5-dihydro-1H-imidazole
Prefaxil
1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-
2-benzyl-2-imidazoline
tolazoline
Imidalin
MFCD00005182
2-Benzyl-4,5-dihydroimidazole
Divascol
2-Benzylimidazoline
Olitensol
Priscoline

Biological Activity

[Description]:

Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Others

[References]

[1]. Tolazoline, From Wikipedia

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
338.2±21.0 °C at 760 mmHg

[ Melting Point ]:
66-69 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₂N₂

[ Molecular Weight ]:
160.216

[ Flash Point ]:
158.3±22.1 °C

[ Exact Mass ]:
160.100052

[ PSA ]:
24.39000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.596

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ1925000

CHEMICAL NAME :: 2-Imidazoline, 2-benzyl-

CAS REGISTRY NUMBER :: 59-98-3

BEILSTEIN REFERENCE NO. :: 0128757

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H12-N2

MOLECULAR WEIGHT :: 160.24

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 62500 ug/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S28-S36/37/39-S45

[ WGK Germany ]:
3

[ RTECS ]:
NJ1925000

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%