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CP-640186 hydrochloride

Names

[ CAS No. ]:
591778-70-0

[ Name ]:
CP-640186 hydrochloride

[Synonym ]:
9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)
Methanone, 9-anthracenyl[(3R)-3-(4-morpholinylcarbonyl)[1,4'-bipiperidin]-1'-yl]-, hydrochloride (1:1)
CP-640186 hydrochloride
CP-640186 (hydrochloride)

Biological Activity

[Description]:

CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase
Research Areas >> Metabolic Disease

[References]

[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.

[2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.


[Related Small Molecules]

ND-630 | ND-646 | TOFA | PF 05175157 | Olumacostat glasaretil | MK-4074 | CP-640186

Chemical & Physical Properties

[ Molecular Formula ]:
C30H36ClN3O3

[ Molecular Weight ]:
522.078

[ Exact Mass ]:
521.244507

[ Storage condition ]:
2-8℃

Related Compounds