(E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylamino)acetate

Names

[ Name ]:
(E)-Methyl 2-(2-Methoxy-5-((2′,4′,6′-triMethoxystyrylsulfonyl)Methyl)phenylamino)acetate

[Synonym ]:
methyl-{N-[2-methoxy-5-methylene(2',4',6'-trimethoxystyrylsulfonyl)-phenyl]amino}acetate
methyl (E)-2-(5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenylamino)acetate
methyl 2-(5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenylamino)acetate
(E)-2,4,6-trimethoxystyryl-3-(carbomethoxymethylamino)-4-methoxybenzyl-sulfone
(E)-2,4,6-trimethoxystyryl 3-(carbomethoxymethylamno)-4-methoxybenzyl-sulfone

Biological Activity

[Description]:

Anticancer agent 9, a glycine derivative, is an anticancer agent. Anticancer agent 9 can inhibit tumor cells viability of myelogenous leukemia and human prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Anticancer agent 9 (compound 24) (96 h) inhibits the cell growth, with IC50s of 0.1 μM and 0.1 μM for K562 and DU145 cells, respectively[1].

[References]

[1]. Pallela VR, et, al. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910•Na (Rigosertib®), a phase III clinical stage anti-cancer agent. Org Biomol Chem. 2013 Mar 28;11(12):1964-77.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₇NO₈S

[ Molecular Weight ]:
465.51700

[ Exact Mass ]:
465.14600

[ PSA ]:
117.77000

[ LogP ]:
4.04540