Tetraethyl heptane-1,7-diylbis(phosphonate)

Names

[ Name ]:
Tetraethyl heptane-1,7-diylbis(phosphonate)

[Synonym ]:
MFCD24539458

Biological Activity

[Description]:

Tetraethyl heptane-1,7-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.202g/cm3

[ Boiling Point ]:
494.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₃₄O₆P₂

[ Molecular Weight ]:
332.35100

[ Flash Point ]:
252.8ºC

[ Exact Mass ]:
332.13700

[ PSA ]:
81.87000

[ LogP ]:
2.52220

[ Index of Refraction ]:
1.543

Tetraethyl heptane-1,7-diylbis(phosphonate)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds