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Tetraethyl decane-1,10-diylbis(phosphonate)

Names

[ CAS No. ]:
5943-62-4

[ Name ]:
Tetraethyl decane-1,10-diylbis(phosphonate)

[Synonym ]:
1,10-Bis-(O,O-diethyl-phosphono)-decan
Decan-diphosphonsaeure-(1,10)-tetraethylester
tetraethyl decane-1,10-diyldiphosphonate
TETRAETHYL DECAMETHYLENEDIPHOSPHONATE
Decamethylen-bis-(diethylphosphonat)
tetra-ethyl decylene diphosphonate

Biological Activity

[Description]:

Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C18H40O6P2

[ Molecular Weight ]:
414.45400

[ Exact Mass ]:
414.23000

[ PSA ]:
90.68000

[ LogP ]:
6.63940

Synthetic Route


Related Compounds