Cinchonine hydrochloride

Names

[ Name ]:
Cinchonine hydrochloride

[Synonym ]:
Cinchonan-9-ol, (9S)-, hydrochloride (1:1)
Cinchonan-9-ol, hydrochloride, (9S)-
Hydrogen chloride (9S)-cinchonan-9-ol (1:1:1)
cinchonan-9-ol,monohydrochloride, (9s)-
cinchonine hydrochloride hydrate
cinchonine hydrochloride dihydrate
cinchonine hydrochloride
cinchodinine dihydrochloride
cinchonine monohydrochloride dihydrate
cinchonine hydrochloride, hydrate
Cinchonan-9-ol, chloride, hydrogen salt, (9S)- (1:1)
l-cinchonine hydrochloride

Biological Activity

[Description]:

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound present in Cinchona bark. Cinchonine hydrochloride activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.

Chemical & Physical Properties

[ Boiling Point ]:
464.5ºC at 760 mmHg

[ Melting Point ]:
208-218ºC(lit.)

[ Molecular Formula ]:
C₁₉H₂₃ClN₂O

[ Molecular Weight ]:
330.852

[ Exact Mass ]:
330.149902

[ PSA ]:
36.36000

[ LogP ]:
3.90450

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD2962020

CHEMICAL NAME :: Cinchonan-9-ol, monohydrochloride, (9S)-

CAS REGISTRY NUMBER :: 5949-11-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2-O.Cl-H

MOLECULAR WEIGHT :: 330.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2550093

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

Safety Information

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36/37-26

[ RIDADR ]:
UN 1544

[ WGK Germany ]:
3

[ RTECS ]:
GD2962020

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)