Azido-PEG2-azide

Names

[ Name ]:
Azido-PEG2-azide

[Synonym ]:
1,8-Diazido-3,5-dioxaoctane
bis-1,2-(2-azidoethoxy)ethane
diazido triethyleneglycol
1,2-bis(2-azidoethoxy)-ethane
1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane

Biological Activity

[Description]:

Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.15 g/cm3

[ Molecular Formula ]:
C₆H₁₂N₆O₂

[ Molecular Weight ]:
200.19800

[ Exact Mass ]:
200.10200

[ PSA ]:
117.96000

[ LogP ]:
0.89332

Azido-PEG2-azide

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds