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Yuanhuacine

Names

[ CAS No. ]:
60195-70-2

[ Name ]:
Yuanhuacine

[Synonym ]:
Odoracin
From gnidia
gnidilatidin
Stillingia factor S6,gnidilatidin

Biological Activity

[Description]:

Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368.

[2]. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
765.9ºC at 760 mmHg

[ Molecular Formula ]:
C37H44O10

[ Molecular Weight ]:
648.73900

[ Flash Point ]:
236.9ºC

[ Exact Mass ]:
648.29300

[ PSA ]:
144.28000

[ LogP ]:
3.70440

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VW7800000
CHEMICAL NAME :
Simplexin, 12-(benzoyloxy)-22,23,24,25-tetradehydro-, (12-beta,22E,24E)-
CAS REGISTRY NUMBER :
60195-70-2
LAST UPDATED :
199009
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C37-H44-O10
MOLECULAR WEIGHT :
648.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
8400 nmol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,45,1986

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream