Braylin

Names

[ Name ]:
Braylin

[Synonym ]:
6-methoxyseselin
2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 6-methoxy-8,8-dimethyl-
6-Methoxy-8,8-dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one
HMS2622L11

Biological Activity

[Description]:

Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[References]

[1]. Renan Fernandes Espírito-Santo, et al. The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches. PLoS One. 2017 Jun 8;12(6):e0179174.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
441.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₄O₄

[ Molecular Weight ]:
258.269

[ Flash Point ]:
198.5±28.8 °C

[ Exact Mass ]:
258.089203

[ PSA ]:
48.67000

[ LogP ]:
3.15

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.570

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%